Cerebellar Purkinje cell activity drives motor learning
نویسندگان
چکیده
منابع مشابه
Impact of NMDA Receptor Overexpression on Cerebellar Purkinje Cell Activity and Motor Learning
In many brain regions involved in learning NMDA receptors (NMDARs) act as coincidence detectors of pre- and postsynaptic activity, mediating Hebbian plasticity. Intriguingly, the parallel fiber (PF) to Purkinje cell (PC) input in the cerebellar cortex, which is critical for procedural learning, shows virtually no postsynaptic NMDARs. Why is this? Here, we address this question by generating and...
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The cerebellum plays a key role in the acquisition and execution of motor tasks whose physiological foundations were postulated on Purkinje cells' long-term depression (LTD). Numerous research efforts have been focused on understanding the cerebellum as a site of learning and/or memory storage. However, the controversy on which part of the cerebellum participates in motor learning, and how the ...
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Cerebellar motor learning is required to obtain procedural skills. Studies have provided supportive evidence for a potential role of kinase-mediated long-term depression (LTD) at the parallel fiber to Purkinje cell synapse in cerebellar learning. Recently, phosphatases have been implicated in the induction of potentiation of Purkinje cell activities in vitro, but it remains to be shown whether ...
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The improvement of motor behavior, based on experience, is a form of learning that is critically dependent on the cerebellum. A well studied example of cerebellar motor learning is short-term saccadic adaptation (STSA). In STSA, information on saccadic errors is used to improve future saccades. The information optimizing saccade metrics is conveyed by Purkinje cells simple spikes (PC-SS) becaus...
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Behavioural learning ismediatedbycellularplasticity, suchas changes in the strengthof synapses at specific sites inneural circuits.The theoryof cerebellarmotor learning reliesonmovement errors signalled by climbing-fibre inputs to cause long-term depression of synapses fromparallel fibres toPurkinje cells.However, a recent review has called intoquestion thewidelyheld view that theclimbing-fibre...
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ژورنال
عنوان ژورنال: Nature Neuroscience
سال: 2013
ISSN: 1097-6256,1546-1726
DOI: 10.1038/nn.3576